Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury
نویسندگان
چکیده
منابع مشابه
Decrease in Cavity Size and Oligodendrocyte Cell Death Using Neurosphere-Derived Oligodendrocyte-Like Cells in Spinal Cord Contusion Model
Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to coun...
متن کاملp43: secondary demyelination in spinal cord injury
the pathology of spinal cord injury (sci) comprises multiple processes characterized by extensive cell death and glial scar formation, which together limits axonal regeneration. in particular, variations in chronic demyelination of the lesion have been found to be largely independent of injury intensity, suggesting a secondary pathologic origin. this chronic demyelination results in progressive...
متن کاملNatural Polyphenols and Spinal Cord Injury
Polyphenols have been shown to have some of the neuroprotective effects against neurodegenerative diseases. These effects are attributed to a variety of biological activities, including free radical scavenging/antioxidant and anti-inflammatory and anti-apoptotic activities. In this regard, many efforts have been made to study the effects of various well-known dietary polyphenols on spinal cord ...
متن کاملTumefactive demyelination of the spinal cord.
Demyelinating lesions of the brain have been frequently reported to mimic tumors, whereas very few cases of tumefactive demyelination of the spine have been reported. We report a patient with tumefactive demyelination of the spinal cord who was clinically, by MRI, and by frozen section diagnosed with tumor and had complete surgical resection. Hence patients with spinal cord lesions suspicious o...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 2006
ISSN: 0022-3069
DOI: 10.1097/01.jnen.0000235855.77716.25